Well, Avast could be an "issue". I also use OS 10.12.6 on both of my Macs, and like you, I have Malwarebytes, Google Chrome, Opera, and Firefox installed (along with quite a lot of other third party software). I primarily use Google Chrome for my internet browsing, but sometimes Opera.
Not sure why you are having the issue. Are you making backups to an external device? And have you ever done any disk cleanup/maintenance/repairs from a software perspective? Besides doing a "good amount" of disk cleanup yourself, there are some excellent products available (both free and commercial) which can help you with those tasks.